Palo Santo is deeply connected to spiritual and shamanic traditions in South America. Ceremonies often use it to cleanse spaces, clear away negative energy, and prepare for sacred rituals. Many believe its scent can heighten awareness and connect individuals to the spiritual realm.

Indigenous communities have a long history of using traditional methods for cleansing and healing. Burning sacred herbs like Sage, Cedar, Palo Santo, and Sweetgrass is a common practice. The smoke from these herbs is thought to purify the mind, body, and soul, bringing balance and harmony.